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The “Call for a Renaissance of the Spirit in the Humanities”, written by Dr Athena D. Potari, is a pioneering project aiming to raise awareness regarding how the prevailing paradigm of materialism affects the ways in which knowledge is approached within the context of the Humanities. In line with the Galileo Report, which discusses the importance of liberating the positive sciences from the limitations of the paradigm of scientific materialism, this Call aims at making the case for the Humanities as well. The Call explores how recent developments in scientific studies on consciousness, and the ensuing understanding that consciousness is primary and unified, can inform our understanding of what it means to be “human” with correspondingly appropriate epistemologies, as well as how we approach key areas of human activity, including ethics, politics and the environment.