In this paper, an extended approach to the philosophical term of Karma is presented, suggesting a high compatibility between its traditional (initiatically transmitted, especially Buddhist) and scientific interpretation. Blending of both apparently dissimilar concepts is meant to reach a more synoptic perspective on this widely known doctrine, which basically addresses a universal law of nature and its impact on individual and collective worldlines. The Informational essence of the Self, with its collective interaction modalities via subtle energy dynamics, as well as the causal interactions at the background of predetermined evolutionary vectors are discussed. Morality and well-being are hypothetically defined in terms of modulating agents of individual and collective behavior guidelines, acting in the framework of a neutral but purposeful evolutionary context, embedded in sequentially higher implicate informational control domains, thus fulfilling the ultimate requirements of the great cosmic harmony we are part of.