Three unsolved problems in deep physics are uncertainty, symmetry-breaking, and dark energy. The life-scientists are in deep search of the minimum criteria of life, from the result of observation of the behavior of a live entity. Psychology, although, is not recognized as a discipline of science, psychiatry remains an important discipline of medical science. Psychology and psychiatry meet on an emerging new epidemic of three overlapping disorders, anxiety, stress and depression. This paper develops the connecting thread between three unsolved problems of physics, three signs of life at the subtle level, and etiopathogenesis of three common psychiatric disorders from the evidence available in cell biology.