Rupert and well-known skeptic Michael Shermer explore the boundaries of human understanding and the nature of scientific knowledge. Shermer argues that while we can never be entirely certain about anything, the scientific method is the best tool we have for approximating truth. He emphasizes the importance of replication in scientific studies and is skeptical of claims that challenge established scientific theories without strong evidence. Sheldrake, on the other hand, believes that there are areas of human experience currently considered taboo in mainstream science that deserve investigation. He argues that the skepticism towards such phenomena is often rooted in a materialist worldview that limits the scope of scientific inquiry. Both agree on the importance of evidence but differ on what constitutes sufficient evidence to challenge existing paradigms.